Levofloxacin hydrochloride

Levofloxacin HCl, a hydrochloride salt form of Levofloxacin is a broad-spectrum fluoroquinolone antibiotic. It is also an optical S-(-) isomer of Ofloxacin. The compound is a DNA gyrase inhibitor that inhibits topoisomerase IV. It treats a wide range of infections including Nosocomial Pneumonia, Community-Acquired Pneumonia, Complicated and uncomplicated Skin, and Skin Structure Infections, Uncomplicated Skin, and Skin Structure Infections, Chronic Bacterial Prostatitis, Inhalational Anthrax (Post-Exposure), Plague, Complicated & uncomplicated Urinary Tract Infections, Acute Pyelonephritis, Acute Bacterial Exacerbation of Chronic Bronchitis, Acute Bacterial Sinusitis among others. Levofloxacin is sold under the brand names Levaquin, Tavanic, Iquix among others. There are very severe adverse side effects associated with these medicines so must be taken only upon a prescription from a doctor, exactly as indicated, and for not more than 14 days. Takeda Chemical Industries, Ltd. filed for a patent in 1984, it was later approved for sale in 1996. However, after the expiry of the protection of the initial patent, it is now made as a generic drug around the world by several manufacturers. It is one of the most commonly prescribed medicines in the USA and has found a place on WHO’s a list of essential medicines.

Dosage and Administration

Levofloxacin is sold as Tablets in 250 mg, 500 mg, or 750 mg strengths administered orally every 24 hours. The dosage for Nosocomial Pneumonia is 750 mg, take once a day for 7 to 14 days. For Community-Acquired Pneumonia, the dose is500 mg – 750mg, taken for 5 or 7 to 14 course, based on the type. For Complicated Skin and Skin Structure Infections, the dose is 750 mg, taken once a day for 7 to 14 days. For Uncomplicated, the dose is 500 mg for 7 to 10 days. for Chronic Bacterial Prostatitis, the dose is 500 mg taken for 28 days. for treating Inhalational Anthrax, Post-Exposure, adult and pediatric patients weighing 50 kg or greater, are given 500 mg for 60 days. for Plague, adult, and pediatric patients weighing 50 kg or greater, the dose is 500 mg, for 10 to 14 days, and for Pediatric patients weighing 30 kg to less than 50 kg, consult the doctor. For treating Complicated Urinary Tract Infection or Acute Pyelonephritis, the dose is 750 mg taken for 5 days.

The price of Levofloxacin

In the USA, The consumer has to pay an average cost of $168.99 for 10 Tablets of 500mg each. The same supply of 10 tablets of 500mg costs USD 10 in India.

How does it work?

Levofloxacin exerts its actions like other fluoroquinolone antimicrobials. It gets involved in inhibiting bacterial topoisomerase IV and DNA gyrase, both of which are type II topoisomerases and are enzymes required for DNA replication, transcription, repair, and recombination. By inhibiting those, the medicine is able to result in the death of bacteria.

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