Indapamide
Indapamide is a diuretic. It treats high blood pressure or hypertension. As a 'water pill,' it is used to reduce the swelling and fluid retention caused by heart disease also being used to treat high blood pressure. It’s actions help the kidneys get rid of unneeded water and salt from the body into the urine.
High blood pressure increases the workload of the heart and arteries. Over a period, the heart and arteries become unhealthy and don’t function well as a reason. It also damages blood vessels of the brain, heart, and kidneys resulting in a heartstroke, heart failure, or kidney failure in addition to increasing the risk of heart attacks. These risks are averted or managed by controlling the blood pressure.
Indapamide is sold under the brand names Natrilix, Indipam XL, Rawel XL, Tensaid XL and Alkapamid XL.
Delalande Sa created the first programmed-release tablet of water-soluble salts of cinepazide and process for preparing it in 1985 and received the patent for it in 1987. However, Laboratoires Servier SAS currently own one of the patents for extended-release tablets and their process of manufacturing. Indapamide is a diuretic that was approved by the FDA in 1983.
Forms and dosage:
Indapamide is available as tablets in increasing strengths of 1.25mg to 2.5mg. in the treatment of Edema, the usual recommended adult dose is 2.5 mg as an initial dose, which can be increased to 5mg as per the need. In the treatment of Hypertension, the usual recommended daily dose starts at 1.25 mg, which can be increased to 4mg as needed.
The price of Indapamide
In the USA, the consumers must pay an average retail price of $18.61 for 30 tablets of a generic brand of 1.25mg strength. The prices are significantly lower in the developing world. In India, the consumer must pay less than US$2 for 30 tablets of 1.5mg.
How does it work?
Indapamide makes the kidneys increase the elimination of sodium, potassium, and water in the urine, causing increased urination. This eventually lowers blood pressure by reducing the fluid in blood vessels and body tissues. By increasing urinary excretion of sodium and water by inhibiting sodium reabsorption in the cortical diluting tubule of the nephron it helps relieve oedema. Its Antihypertensive effect is unknown; however, it has been suggested that it leads to direct arteriolar vasodilatation through calcium channel blockade.
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