Hydroxychloroquine is an aminoquinoline like chloroquine. It is a commonly prescribed
medication in the treatment of Rheumatoid arthritis, a condition causing inflammation of the
joints, Juvenile idiopathic arthritis in children, Discoid and systemic lupus, a disease of the
skin or the internal organs and skin problems which are sensitive to sunlight.
Hydroxychloroquine is also used for prevention of a process that can lead to malaria in
regions where chloroquine is unlikely to find resistance. It was investigated for the treatment
of SARS-CoV-2 and found not be effective.
Winthrop Developed Hydroxychloroquine and was granted FDA approval in 1955. It was
developed during World War II as a derivative of quinacrine. The FDA emergency use
authorization for hydroxychloroquine and chloroquine in the treatment of COVID-19 was
revoked in June 2020.
Dosage Forms & Strengths
Hydroxychloroquine is sold in the tablet form of 200mg. in the treatment of Malaria, the
Indicated for prophylaxis of malaria in geographic areas where chloroquine resistance is not
reported is 400 mg /weekly, starting 2 weeks before exposure and continued for 4 weeks after
departure from an endemic area. In the treatment of Rheumatoid Arthritis, Indicated for the
treatment of acute and chronic rheumatoid arthritis is 400-600 mg/day and in the treatment of
Lupus, the indicated dosage is 200-400 mg/day
The wholesale cost of hydroxychloroquine
The cost for hydroxychloroquine oral tablet 200 mg is around $37 for a supply of 100 tablets,
depending on the pharmacy you visit in the USA, the prices can start from USD 19 and go up
ot USD 50 based on generic or otherwise brands. In the developing world, in India, the same
tablets cost as low as 20 cents, which is a total of 30 USD for a month’s supply.
How does it work?
Hydroxychloroquine sulfate works by reducing inflammation in people with autoimmune
diseases when the body's immune system attacks itself by mistake. Antimalarial agents like
chloroquine and hydroxychloroquine have several pharmacological actions that may be
involved in their therapeutic effect in the treatment of rheumatic disease, but the role of each
is not known.
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