Hyaluronidases consist of a family of drugs that catalyse the degradation of hyaluronic acid. Its synthesis was first patented in the US in 1957 and later in 1971, the enzyme was subclassified by Karl Meyer into three distinct groups, revolving around a scheme based on the enzyme reaction products. With the three main classes consisting of two variations of eukaryotic endoglycosidase hydrolases and the final class a prokaryotic lyase-type of glycosidase. Hyaluronidases manufacturers and hyaluronidases suppliers have since commercialised the product, with distributors frequently listing it for sale on the global marketplace at an array of price points, being sold under brand names including Vitrase. Hyaluronidases manufacturers and hyaluronidases suppliers, however, typically produce it in combination with other pharmaceutical products as hyaluronidases acts to speed their dispersion and delivery in the body. As such, it is predominantly used to enhance the permeation of subcutaneous or intramuscular injections, local anaesthetics, and subcutaneous infusions, and to promote resorption of excess fluids and blood in the tissues.
Method of action of hyaluronidase:
Hyaluronidase is an enzymatic medication which is classified into the family of hyaluronoglucosidases according to its enzymatic mechanism, cleaving the linkages between N-acetylglucosamine and glucuronate. This permits the catalyzation of hyaluronan through hydrolysis. As hyaluronan is a constituent component of the extracellular matrix, hyaluronidase lowers the viscosity of hyaluronan and thus increases tissue permeability due to the disruption of the extracellular matrix.
Form and dosage of hyaluronidase:
Hyaluronidase is predominantly produced by manufacturers in injection, solution, and lyophilized powder for solution form. With the packaging similarly dependent on the specific wholesale company or distributor, as well as the for-sale list of the manufacturer. Hyaluronidase is a prescription-only medication, as such, it is only administered under the guise of a healthcare professional. Where typical doses vary significantly pertaining to the underlying cause of administration and medical prerogative, with 1500 units dissolved in 1 mL water for injections or 0.9% sodium chloride and infiltrated into affected area usual for both local infiltrations due to haematomas and extravasation, and subcutaneous injections due to hypodermoclysis. For uses pertaining to enhancing the permeation of local anaesthetics and subcutaneous or intramuscular injections, 15 units/mL or 1500 units mixed with the solution to be injected is recommended.
Hyaluronidase on Pipelinepharma:
Searching on our online Pipelinepharma marketplace reveals an array of B2B wholesale sellers with hyaluronidase available to order. At the time of current writing, two trusted providers situated in the United States and South Korea contain hyaluronidase on their list. These manufacturers and distributors have been verified by the Pipelinepharma team according to strict quality control. Ensuring trust between both parties and expediting transactions.
Price of hyaluronidase and how to buy:
As with other pharmaceutical products listed on the Pipelinepharma marketplace, the specific cost of hyaluronidase remains negotiable online between both B2B parties through the Pipelinepharma interface. This allows for flexibility and ease of negotiability. However, if desired the manufacturer or supplier may choose to include the desired cost for their product, facilitating trade and providing a base for further negotiation. If this is indicated, an ‘Accept’ and ‘Negotiate’ button will be shown, with a ‘Get offer’ button being displayed in the absence of a listed price.