Fluvastatin is used in the treatment of patients with heart ailments. It is a statin, so Fluvastatin
is prescribed together with diet, weight loss, or fitness regimen to decrease the risk of heart
attacks and strokes. The long terms benefit is that the patients are saved the trouble of going
through heart surgeries. Fluvastatin usage reduces the risk of developing heart disease. It is
also prescribed for patients to decrease the levels of fatty substances such as Low-density
cholesterol (bad) and triglycerides while increasing high-density cholesterol (Good).
Fluvastatin is a type of medication called HMG-CoA Reductase inhibitors, which has the
the distinction of being the first one to be entirely synthetically made and it is different than the
other inhibitors extracted from fungal derivatives.
Fluvastatin is sold under the brand names Lescol, Canef, and Vastin to name a few
The Japanese biochemist Akira Endo working for Sankyo Company in 1976, isolated a factor
from the fungus Penicillium citrinum which he identified as a competitive inhibitor of HMG-
CoA. Fluvastatin was one of the four variants of statin discovered in labs since the 1970s,.
Fluvastatin was first patented in 1982 and received approved for medical use in 1994.
Forms and Dosage
Fluvastatin comes is sold in the form of a capsule and an extended-release (long-acting) tablet
to take by mouth. The standard recommended dosage ranges from 20mg to 80 mg daily.
Fluvastatin is mostly taken once in the evening or sometimes twice a day. In the treatment of
Hypercholesterolemia, adult patients are prescribed a starting dose of 20mg – 40 mg, if the
daily dose has been set at 80mg, it is recommended to take it two dosages 12 hours apart.
Amongst patients who are aiming to decrease the bad cholesterol the recommended dosage is
20mg per day.
How does Fluvastatin work?
Fluvastatin actions slow down the production of cholesterol, in the process decreasing the
amount of cholesterol that may build up on the walls of the arteries and block blood flow to
the heart, brain, and other parts of the body. Cholesterol accumulation and fats on walls
arteries decreases blood flow and, as a result, inhibits the oxygen supply to vital organs such
as the heart, brain, amongst other organs. Fluvastatin blocks the liver enzyme HMG-CoA
Reductase, this action of Inhibition results in a decrease in bad cholesterol.
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