Flucloxacillin Sodium is an antibiotic. Flucloxacillin Sodium used to treat infections caused by
sensitive Gram-positive organisms, including β-lactamase producing staphylococci and
streptococci. It is used to treat skin and soft tissue infections like Boils, cellulitis, abscesses,
infected burns & skin conditions like ulcer, eczema, and acne, provides protection for skin
grafts, carbuncles, furunculosis, infected wounds, and impetigo. It is also used to treat
Respiratory tract infections like Pneumonia, lung empyema, sinusitis, abscess, pharyngitis,
tonsillitis, quinsy, otitis media, and externa. Other infections that are treated using Flucloxacillin
Sodium include Osteomyelitis, enteritis, meningitis, urinary tract infection, septicemia, and
endocarditis. It is also used as a prophylactic agent during major surgical procedures like
cardiothoracic and orthopedic surgery, when appropriate.
Flucloxacillin Sodium is sold under the brand name Clox-F, Cloxafu, and Dolopen among
Flucloxacillin’s first patent was filed in 1961 but as of 2011, it is not commonly prescribed in the
USA and Canada.
Dosage and Administration
Flucloxacillin Sodium’s dosage depends on the severity of the infection, age, weight, and other
factors. The recommended usual adult dosage is 250mg, taken four times a day, which can be
doubled to 500mg for serious infections. In the treatment of endocarditis Osteomyelitis to dose
is up to 8g daily, given every 6-8 hours. In Surgical prophylaxis, the dose is 1 to 2g, through an
IV at beginning of anesthesia. This is followed by a dose of 500mg, taken every six hours,
through Intravenous or intramuscular injection or orally for up to 72 hours. For the Paediatric
population in the age group 2-10 years, the dose is 125mg, taken four times a day, and for kids
under 2years of age, the dose is 62.5mg, take four times a day.
The price of Flucloxacillin Sodium
In India, the medicine Grade Flucloxacillin Sodium Powder costs USD 34 per kilo. In the UK,
each 250mg tablet cost around £1.80.
How does it work?
Flucloxacillin sodium is a narrow-spectrum antibiotic. It is from the family of the penicillin group
of antibiotics. Its actions break down the bacterial cell wall. Similar to other β-lactam antibiotics
like it, Flucloxacillin inhibits the synthesis of bacterial cell walls and cross-linkage between the
linear peptidoglycan polymer chains. These polymer chains form a major component of the cell
wall of Gram-positive bacteria. As Flucloxacillin is more acid-stable compared to other
Penicillins it can be taken orally and through parenteral routes. However, similar to Methicillin, it
is less potent than benzylpenicillin against non-β-lactamase-producing Gram-positive bacteria.
Its pharmacokinetics, antibacterial activity, and uses are the same as Dicloxacillin, and both are
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