Fasudil is a potent Rho-kinase inhibitor and vasodilator. It is widely prescribed for the treatment of cerebral vasospasm often caused by a subarachnoid hemorrhage. It helps improve cognitive decline in patients of stroke. Moreover, It has also been effectively used for the treatment of pulmonary hypertension and a promising drug for a new therapy of amyotrophic lateral sclerosis.
It is sold as Chuanwei made by Chase Sun Pharmaceutical in china and as Eril by Asahi Kasei Pharma, in Japan. It has been approved for sale in Japan and China, but is yet to be approved by the United States Food and Drug Administration or by the European Medicines Agency.
Dosage:
Fasudil is sold as 30 mg tablets can be dissolved in 20 mL of saline and 15–45 cc of this solution can be infused through a microcatheter at a rate of 1–2 cc/min. a higher dosage has been associated with serveral complications.
Cost of Fasudil
A vial containing 30mg in a 2ml vial costs around usd50 in countries where it has been approved for sale.
How does it work?
Fasudil is a selective RhoA/Rho kinase (ROCK) inhibitor. This inhibitor is an enzyme that plays an important role in mediating vasoconstriction and vascular remodeling in the pulmonary hypertension. ROCK causes vasoconstriction by binding subunit of myosin light chain phosphatase, thus decreasing phosphatase activity which causes the problem and enhancing vascular smooth muscle contraction.
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