Eribulin Mesylate monotherapy is for treating locally advanced or metastatic breast cancer
called unresectable liposarcoma, which has progressed even after at least one
chemotherapeutic regimen for the advanced stage of the disease. it is given to those whose
earlier therapies included an anthracycline and a taxane, given the patient was suitable for their
regimen. It treats adults with prior anthracycline-containing therapy. It is an anticancer
medication called microtubule dynamic inhibitor that stops cancer cells from growing and
spreading. Eribulin Mesylate is a synthetic analog of halichondrin B derived from a marine
sponge called Lissodendoryx sp with antineoplastic activity.
Eribulin Mesylate is sold under the brand name Halaven made by Mylan.
Eisai Research Institute developed Eribulin mesylate. Later in 1985, Japanese, Hirata, and
Uemura, first isolated halichondrin B from the natural Japanese marine sponge Halichondria
okadai and later from other sponges of Axinella, Phakellia, and Lissodendoryx families.
Dosage and Administration:
Eribulin Mesylate is available as a clear, colorless, sterile solution for intravenous
administration. Every vial has 1 mg of Eribulin Mesylate as a 0.5 mg for 1mL solution in ethanol
and water in the ratio of 5:95. As a therapy for metastatic Breast Cancer, it is for those who had
used two chemotherapeutic regimens including an anthracycline and a taxane. In the treatment
of Liposarcoma, it is for women with unresectable or metastatic liposarcoma who have received
a prior anthracycline therapy. The recommended dose is 1.4 mg for m². It is administered
intravenously over 2 to 5 minutes on Days 1 and 8 of a 21-day cycle of the therapy.
Eribulin Mesylate Price:
In India, a Pune-based company sells one vial of USD260, taking the cost of the course of
treatment to USD4100, the brand Halaven sells a vial for USD430, charging roughly USD 6800
for the course. Whereas in the USA, the consumer pay an average price is $1037 for the 1-mg/2
mL vial taking the cost of each dose to $2488, or $4977 per treatment cycle.
How does Eribulin Mesylate work?
Eribulin Mesylate is a fully synthetic macrocyclic ketone analog of natural products of marine
sponge. Its actions block the growth of microtubules via a tubulin-based antimitotic mechanism.
This results in the blocking of the G2/M cell-cycle leading to a disruption of mitotic spindles. This
eventually results in ultimately, apoptotic cell death after prolonged mitotic blockage. As an
antineoplastic agent and a microtubule-destabilizing agent, its combined actions potentially lead
to tumor regression.
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