ERIBULIN MESYLATE

Eribulin Mesylate monotherapy is for treating locally advanced or metastatic breast cancer called unresectable liposarcoma, which has progressed even after at least one chemotherapeutic regimen for the advanced stage of the disease. it is given to those whose earlier therapies included an anthracycline and a taxane, given the patient was suitable for their regimen. It treats adults with prior anthracycline-containing therapy. It is an anticancer medication called microtubule dynamic inhibitor that stops cancer cells from growing and spreading. Eribulin Mesylate is a synthetic analog of halichondrin B derived from a marine sponge called Lissodendoryx sp with antineoplastic activity. Eribulin Mesylate is sold under the brand name Halaven made by Mylan. Eisai Research Institute developed Eribulin mesylate. Later in 1985, Japanese, Hirata, and Uemura, first isolated halichondrin B from the natural Japanese marine sponge Halichondria okadai and later from other sponges of Axinella, Phakellia, and Lissodendoryx families.

Dosage and Administration:

Eribulin Mesylate is available as a clear, colorless, sterile solution for intravenous administration. Every vial has 1 mg of Eribulin Mesylate as a 0.5 mg for 1mL solution in ethanol and water in the ratio of 5:95. As a therapy for metastatic Breast Cancer, it is for those who had used two chemotherapeutic regimens including an anthracycline and a taxane. In the treatment of Liposarcoma, it is for women with unresectable or metastatic liposarcoma who have received a prior anthracycline therapy. The recommended dose is 1.4 mg for m². It is administered intravenously over 2 to 5 minutes on Days 1 and 8 of a 21-day cycle of the therapy.

Eribulin Mesylate Price:

In India, a Pune-based company sells one vial of USD260, taking the cost of the course of treatment to USD4100, the brand Halaven sells a vial for USD430, charging roughly USD 6800 for the course. Whereas in the USA, the consumer pay an average price is $1037 for the 1-mg/2 mL vial taking the cost of each dose to $2488, or $4977 per treatment cycle.

How does Eribulin Mesylate work?

Eribulin Mesylate is a fully synthetic macrocyclic ketone analog of natural products of marine sponge. Its actions block the growth of microtubules via a tubulin-based antimitotic mechanism. This results in the blocking of the G2/M cell-cycle leading to a disruption of mitotic spindles. This eventually results in ultimately, apoptotic cell death after prolonged mitotic blockage. As an antineoplastic agent and a microtubule-destabilizing agent, its combined actions potentially lead to tumor regression.

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