Dimetindene gives relief from symptoms of allergic reactions like Urticaria, upper respiratory
tract allergies like hay fever, perennial rhinitis, food and drug allergies, pruritus of various
origins, except pruritus caused by cholestasis and insect bites. Dimethindene is also
indicated for pruritus in eruptive skin diseases such as chickenpox. Dimethindene is an
adjuvant in eczema treatment and other allergic pruriginous dermatoses.
Dimetindene is an antihistamine or anticholinergic, which is a first-generation selective H1
antagonist. Dimetindene is atypical of first-generation H1 antagonists because a minimal
amount of this medicine passes across the blood-brain barrier. It also acts as an M2 receptor
antagonist. Dimetindene is sold in its most common forms, maleic acid salt and
Dimethindene is sold under the brand name Fenistil among others.
Merck & Co Inc first patented Dimetindene in, 1958 for its Mastitis aerosol foam. It came in
to medical use in 1960. Later several other formulations were developed around the world, in
the USA, Novartis is the current assignee for its formulation.
Dosage and administration
Dimethindene is sold as a tablet, topical as 0.1% gel, or lotion. If using drops through the oral
route for itching from urticaria, dermatitis, eczema, diabetes, liver disease, leukemia,
lymphogranulomatosis, insect bites, allergies, hay fever, the adult dose is 1 to 2 milligrams
or 20 to 40 drops of a 1-milligram or milliliter solution, taken three times a day. When using
the immediate-release tablet, the dose is 1 to 2 milligrams, three times a day. If using the
sustained-release tablet, the dose is 2.5 milligrams, taken twice a day. If using syrup, the
dose is one teaspoonful or 5 milliliters of a 0.123-milligram syrup, taken up to 9 times a day.
If administering through the parenteral route, the dose is 4 milligrams, administered
intravenously, once or twice a day for during of therapy no longer than 7 days. When it is
used through the topical application route, 0.1% gel should is applied thinly to the affected
skin several times daily.
The cost of Dimethindene
In India, the consumers have to pay around USD4 for a supply of 250 tablets of 1mg
strength. In the USA, the consumers have to pay $ 12.50, for a 20ml Solution, whereas the 30
gr. 0, 1% - 1 Gel costs around $ 14.60.
How does Dimethindene Work?
Dimethindene is a potent M2-selective muscarinic receptor antagonist in the form of a
racemic mixture. It has a lower affinity for M1, M3, and M4 muscarinic receptors, for histamine
H1 receptor binding. Its actions block the action of endogenous histamine, giving temporary
relief from negative symptoms brought on by histamine release.
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