DIMETHINDENE MALEATE

Dimetindene is a potent antipruritic antihistamine that is a selective H1 antagonist, used in the symptomatic treatment of insect bites and sunburns. Its primary form Dimetindene is used for curing allergic reactions like urticaria, allergies of the upper respiratory tract like perennial rhinitis and hay fever, in curing food, and drug allergies, some pruritus, insect bites. It is also used in the treatment of pruritus in eruptive skin diseases like chickenpox, as an adjuvant in the treatment of eczema and other allergies of pruriginous dermatoses origin. Its outstanding characteristic is the small size of its effective doses and the rapid onset of action, which takes effect within 20 to 60 minutes and gives relief for several hours. Dimetindene Maleate is sold under the trade name Forestal and Fenistil among others. Novartis owns the current right for Dimetindene Maleate. However, it first came into use in 1960 after it was patented in the late 1950s.

Dosage and administrations

Dimetindene Maleate is sold as gel, emulsion, drops as well as a syrup that particularly for use in children. One teaspoonful syrup contains 5ml of the drug that is equal to the 0.5mg Coated tablets. The standard recommended dosage for adults is 3-6 tablets. The standard dose varies by age, where if taking the Drops, the dose for Infants up to 1 year is 10-30 drops, for Infants of 1 to 3 years age the dose is 30-45 drops, in treating Children over 3 years, the dose recommended is 45-60 drops and for Adults, the dose is 60-120 drops. If using the Syrup, the standard dose for infants up to 1 year is 1-3 teaspoons and for Infants of 1 to 3 years, the dose is 3-4 teaspoons. For treating children over 3 years the dose is 4-6 teaspoons and for Adults, the dose is 6-12 teaspoons.

The cost of Dimetindene Maleate

In India, the consumers buy 250 Dimetindene Maleate Tablets of 1 Mg for as low as USD4. In Europe, the oral drops of 20 ml cost around EUR 6.61, and the 0.1% concentration gel of 20ml cost around 9 pounds in the UK.

How does Dimetindene Maleate Work?

Dimethindene is a strong and selective histamine H1 antagonist. Its actions bind it to the histamine H1 receptor competing with it. The result of this blocking is the action of endogenous histamine. This whole process eventually leads to temporary relief from the negative symptoms brought on by histamine generation in the body during an allergic reaction.

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