Deferasirox Manufacturers

Deferasirox is an iron chelator belonging to a class of medications called Iron-Chelating agents. Deferasirox is the first oral medication approved by FDA for chronic iron overload in patients receiving blood transfusion for a prolonged use and this medication is also used to treat high levels of iron in people with certain blood disorders who actually do not require blood transfusion. Blood transfusion is often needed in few types of blood diseases such as anemia, sickle cell disease, which leads to additional iron that may build up in the body and cause problems such as diabetes, liver disease, heart failure etc, and deferasirox is used to eliminate the additional iron from the bloodstream and reduces the risk of these diseases.

Before using deferasirox, the risk of taking the drug must be weighed against the benefits it provides. It is always recommended to consult a physician before taking deferasirox as this medication may interact with other drugs or health problems.

Deferasirox is advised as a prescription product as well as generic prescription product. Manufacturers market deferasirox under the Brand name of Exjade, Jadenu. Deferasirox is available in a dosage form of tablet, granules, tablet for suspension in dosage strengths of 90 mg, 125 mg, 250 mg, 500 mg which is taken by mouth once daily on an empty stomach half an hour before meals. Deferasirox tablets are supplied as round, white, film coated tablets imprinted with the first letter of brand name and strength on one side and manufacturer name on the other side in a bottle of 30 tablets.

Deferasirox therapy should be considered only when a patient has proof of iron overload over a long-term blood transfusion, the recommended initial dose of deferasirox in transfusional iron overload patients with 2 years of age and older with estimated glomerular filtrate rate greater than 60 mL/min/1.73 m2 is 20 mg per kg body weight given orally once daily. The recommended initial dose of deferasirox in iron overload in non-transfusion-dependent thalassemia syndromes in patients with eGFR greater than 60 mL/min/1.73 m2 is 10 mg per kg body weight given orally once daily. Deferasirox Tablets are recommended to be stored at 25° C (77° F), in well closed containers with excursions permitted to 15° C to 30° C (59° F to 86° F) with protection from moisture.

Wholesale Price of Deferasirox

The wholesale price for 30 units of 90 mg deferasirox oral tablet is $ 966 with per unit cost comes at $ 32.21 The cost for deferasirox 180 mg oral tablet is around $ 1922 for a supply of 30 tablets with per unit cost available for as low as $ 64 The cost for deferasirox oral granule for reconstitution 90 mg is around $ 914 for a supply of 30 tablets with per unit cost available for as low as $ 30.47

Deferasirox - Mechanism of Action

Deferasirox works by binding to iron in the bloodstream by forming a stable complex which is eliminated through kidneys.

Finding Deferasirox Manufacturers and Suppliers

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