Dacarbazine (DTIC), also known as imidazole carboxamide, is a medication used in chemotherapy for the treatment of various cancers such as melanoma and Hodgkin's lymphoma. For Hodgkin's lymphoma treatment therapies, it is usually used as part of a combination of drugs. With these drugs typically being vinblastine, bleomycin, and doxorubicin, which are administered by way of an injection.
Dacarbazine was originally developed by Y. Fulmer Shealy at the Southern Research Institute in Birmingham Alabama. It was subsequently patented and put to the commercial medical marketplace by the pharmaceutical products manufacturing company Bayer in 1975, post gaining of regulatory approval.
Currently, dacarbazine has found common use in the oncology field, with dacarbazine manufacturers and dacarbazine suppliers listing it for sale and dacarbazine distributors having it readily available for order. Where it can be found across the global marketplace on these pharmaceutical products lists at wholesale for a variety of cost and price points. This popularity is further spurred by it being on the World Health Organization's List of Essential Medicines, indicating that it is a cost-effective and efficient medication recommended for use in global health systems.
Method of action of dacarbazine:
Dacarbazine is a synthetic analogue of a naturally occurring purine precursor 5-amino-1H-imidazole-4-carboxamide and functions through antineoplastic actions. The specific mechanism of dacarbazine remains elusive, however, it is thought that it exerts its cytotoxic effects through its action as an alkylating agent. Other possible methods of actions include inhibition of DNA synthesis through its aforementioned analogic nature to purine and interactions with SH groups. Also noteworthy is that dacarbazine is not cell cycle-phase specific.
Form and dosage of Dacarbazine:
The final form and packaging of dacarbazine are dependent on the manufacturers and suppliers, as well as the specific distributors and order. However, it is typically found for sale wholesale in forms including vials, lyophilized powder for solution, solution for injection, and solution for infusion. Dacarbazine is a specialised medication as such it can only be administered by an accredited healthcare professional. Specific therapeutic amounts will be highly dependent on the individual patient, with adjustments being made based on variables including condition, progression, age, and weight. For more information please refer to the manufacturers’ literature or contact an accredited healthcare provider.
Dacarbazine on Pipelinepharma:
Currently, at the time of writing, we have found 7 verified dacarbazine manufacturers and dacarbazine suppliers from our online global list of B2B sellers. These manufacturers, suppliers, and distributors are located in various countries including Switzerland, Argentina, India, and China. Each company and their pharmaceutical products list displayed on our online B2B platform has been verified by the Pipelinepharma team. This ensures seller reputability and reduces sourcing mileage, allowing for a fluent business experience for all involved parties.
Price of Dacarbazine and how to buy:
A cursory search online reveals an approximate wholesale cost for dacarbazine to be USD 207.25 for 200 mg in powder for solution for injection form. With the price being lower at USD 48.57 for 500 mg dacarbazine in powder for solution for infusion form. These values are indicated for the NHS in the UK. As such they are only intended to serve as a generalization of the current market conditions in a specific area.
Although the prices on the B2B wholesale Pipelinepharma marketplace remain confidential between both B2B parties, the seller may choose to list the desired price to facilitate the online transaction. If so, an ‘Accept’ and ‘Negotiate’ button will be displayed through the online interface, with a ‘Get offer’ button being shown in the absence.