Ceftriaxone sodium is the sodium salt of ceftriaxone – an antibiotic used to treat a variety of bacterial infections, such as meningitis, pneumonia, gonorrhea, and many more. Patients with such indications are administered the drug either intravenously or intramuscularly. It is available in the form of 250mg - 10g Cetriaxone injectable powder. This drug is on the World Health Organisation's list of Essential Medicines that contains the safest and most effective drugs recommended for a health system. It is available both in generic form and as a branded medication. There are over 100 manufacturers and suppliers of trade name drugs worldwide. The most notable example of these is Rocephin, marketed by manufacturer Roche. This pharmaceutical remedy belongs to the cephalosporin class of antibacterial antibiotics. Each member of this class of drugs differs in terms of method of administration, absorption, efficacy, and length of action. Of all of these,this drug is unique in that it has a long-half life, and, as such, can be administered less frequently. Ceftriaxone Sodium is classified as 3rd generation Cephalosporin and is sold under the brand name Rocephin, Epicephin and Wintriaxone among many others. Its legal status is of ‘’Prescription Only Medication’’. This pharmaceutical medicine is excreted 33-67% through kidney and 35-45% through biliary system with the elimination half life 5.8-8.7 hours and a negligible metabolism. Its absorption is high when administered intramuscularly and intravenously. It is not available in a dosage form to be administered orally. Associated common side effects are allergic reaction at the site of injection, Clostridium difficile associated diarrhea, hemolytic anemia , gallbladder disease and seizures. Common adverse effects associated with this drug are thrombocytosis, elevation in liver enzymes, leukopenia, diarrhea, elevation in BUN, and rash, tenderness, irritation at local sites. It is evidenced to be safe during pregnancy. It is excreted into human breast milk in very minute quantities and hence is considered safe to be used by lactating women. This pharmaceutical medicine is contraindicated in dose patients having a history of anaphylaxis to penicillin, hyperbilirubinemia, liver problem, and severe renal impairment. Cautions should be taken while using this medicine in the mentioned conditions. It interacts with many drugs and have serious type of drug interactions with BCG vaccine, Cholera vaccine, Heparin; moderate type of drug interactions with Chloramphenicol, Erythromycin ethyl succinate and Tetracycline; mild type of drug interactions with Furosemide and Rose hips among many others. This drug was patented in 1978 and properly approved to be used in clinical practices in 1982. It is included in the Essential drug list issued by the World Health Organization.

It works by inhibiting bacterial cell wall synthesis by binding to transpeptidases selectively and irreversibly which inhibits the catalyzing of cross linking of peptidoglycan polymers forming the bacterial cell wall. Thus, lysing the bacterial cell wall and exhibiting its static and lytic action.

U.S. prices for Ceftriaxone Sodium powders range from 1.35 USD to 24.50 USD, depending on the quantity purchased, whereas in the EU, 10 sachets of 1g powder typically cost from 6 EUR to 26 EUR. However, these prices may vary based on the drug store you purchase your medication from.

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