Anthocyanidins manufacturers

About anthocyanidins

Anthocyanidins manufacturers are mainly botanical extract producers, such as Indena in Italy, that supply standardised berry extracts for medicines, food supplements and food colours. Anthocyanidins are the coloured plant pigments that give berries, grapes and red cabbage their red, purple and blue colours. They are the sugar-free core (aglycone) of anthocyanins. In pharmaceuticals, anthocyanidin content is mainly used as the quality marker for bilberry and other berry extracts. Companies can source anthocyanidin-standardised extracts and finished products through supply or out-licensing.

Anthocyanidins key facts

Anthocyanidins manufacturers and licensing history

Anthocyanidins are not sold as single pure medicines. They appear in medicines and supplements as part of standardised berry extracts, mainly from bilberry (Vaccinium myrtillus). The most studied extract contains 36% anthocyanosides, equal to 25% anthocyanidins, and is produced by Indena of Milan as Myrtocyan and Mirtoselect.

Other producers make extracts from blackcurrant, elderberry, grape and other berries for supplements and food colours. Anthocyanins from purple carrot, red cabbage and grape skin are widely used as natural food colours.

Anthocyanidin content depends on the test method. UV methods measure total anthocyanidins, while HPLC measures individual anthocyanins. Buyers should confirm the test method, plant source, authenticity testing and GMP status before choosing a supplier, because cheaper extracts are sometimes adulterated with other berries or dyes.

Anthocyanidins dosage forms and dossier types

Anthocyanidins are supplied as part of standardised extracts, which go into capsules, tablets and food products.

Anthocyanidins regulatory and patent status

Anthocyanidins have no standalone medicinal approval. Their main medicinal use is through bilberry extract, covered by the EU HMPC monograph on fresh bilberry fruit, which specifies a dry extract with 36% anthocyanosides, corresponding to 25% anthocyanidins. Anthocyanins are also authorised as a food colour. As natural substances, they are not patentable, but specific extracts and processes may be protected.

Anthocyanidins mechanism of action and therapeutic use

Anthocyanidins are antioxidants that help strengthen small blood vessels and reduce capillary leakage. In bilberry extracts, they are used for symptoms of minor venous circulation problems, such as heavy legs, and for fragile capillaries in the skin. They have also been studied for eye health, although evidence for night vision is limited.

Anthocyanidins licensing and sourcing

Anthocyanidin suppliers typically offer standardised extracts, finished products or dossier out-licensing. Buyers usually compare extract standardisation and test method, authenticity testing, GMP status and territory availability. Current offers and supplier contacts are listed among the anthocyanidins manufacturers on Pipelinepharma.

Frequently asked questions about anthocyanidins

Who are the main anthocyanidins manufacturers? Indena of Milan is the best-known producer of bilberry extract standardised to anthocyanidins. Many other botanical extract companies supply berry extracts and natural food colours.

What is the difference between anthocyanidins and anthocyanins? Anthocyanins are the natural pigments with a sugar attached. Anthocyanidins are the same pigments without the sugar. Bilberry extract with 36% anthocyanins equals about 25% anthocyanidins.

Are anthocyanidins approved as a medicine? Not on their own. They are used in bilberry extract medicines covered by the EU HMPC monograph, and in food supplements.

How is anthocyanidin content measured? Anthocyanidin content is usually measured by UV spectroscopy, while individual anthocyanins are measured by HPLC. Always check which method a supplier uses.

What are anthocyanidins used for? Anthocyanidins are used in bilberry extracts for heavy legs from minor venous problems and for fragile skin capillaries, and as natural food colours.