Almotriptan

Almotriptan is used to treat symptoms of migraine headaches. These symptoms include severe, throbbing headaches, accompanied by nausea and sensitivity to light and sound. Almotriptan is selective serotonin receptor agonists whose actions narrow blood vessels around the brain, which prevents pain signals from being sent to the brain, and blocking the release of substances that cause pain, nausea, and symptoms of migraine. Almotriptan does not cure migraine attacks or nor can it reduce the number of headaches. Since these aches are an impediment to daily functioning, taking prompt treatment helps patients to return to normal routine. Almotriptan is sold under several trade name such as Sumatriptan, Treximet, Imitrex, Imigran amongst others.

GlaxoSmithKline developed Almotriptan and received FDA approval for the treatment of migraine in 1992. Since then, GlaxoSmithKline and Merck in 1998, also received FDA approvals for their second-generation medicine. Janssen Pharms received marketing approval in 2001 for the management of heavy migraine attacks. Pfizer got approval for to medicine as an abortive in migraine attacks in 2002. Endo Pharms and AstraZeneca were given approval in 2001 for the treatment of acute migraine attacks.

Dosage and forms:

Almotriptan is available as a tablet in 6.25mg and 12.5mg strengths. The usual adult dose recommended for acute treatment of migraine attacks in patients with a history of migraine with or without aura starts at 6.25-12.5 mg as an initial dose. The dose is repeated every 2 hours until the desired reduction in pain is achieved. The daily dose of this pain medication should not exceed 25 mg. However, it has been established that the best does to treat adults with is 12.5 mg.

The price of Almotriptan

In the USA, The price of the most common version of Almotriptan starts at around $$460.81 for 12 tablets of 12.5mg strength. However, the price of this medication is significantly cheaper in the developing world. The same supply of 12.5mg, 12 tablets cost U$1.3 in India.

How does Almotriptan work?

Almotriptan is a selective serotonin agonist in the cranial arteries on the 5-HT1B and 5-HT1D receptors. 5HT receptors when activated by Almotriptan reduce neurogenic inflammation, thus in turn getting involved in the migraine relief process. Its actions narrow blood vessels in the brain, reducing the cerebral blood flow. This stops the transmission of pain signals to the brain center. It has a short half-life of 3 hours.

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