Aesculus hippocastanum manufacturers

About Aesculus hippocastanum

Aesculus hippocastanum manufacturers produce standardised horse chestnut seed extracts sold as Venostasin, Venoplant, Aescusan, Aesculaforce and similar products. Aesculus hippocastanum (horse chestnut) seed extract is a herbal medicine for chronic venous insufficiency. Its main active ingredient is aescin. Pharmaceutical companies can source horse chestnut extract capsules, tablets and gels through out-licensing, supply or technology transfer. Dossiers are available as EU well-established-use or traditional-use herbal dossiers.

Aesculus hippocastanum key facts

Aesculus hippocastanum manufacturers and licensing history

Horse chestnut seed has long been used in European herbal medicine for venous disorders. Germany’s Commission E and ESCOP both published monographs supporting its use in chronic venous insufficiency.

Standardised extracts are sold under several brands. Venostasin retard capsules and Venoplant retard tablets each provide about 50 mg aescin per dose. A.Vogel sells Aesculaforce, and Medius markets Venostasin in Switzerland. In Poland, Herbapol sells Aesculan, a rectal ointment and gel that combines horse chestnut bark extract with lidocaine.

Horse chestnut extract is a natural product, so quality depends on the extraction method and standardisation. Buyers should confirm GMP status, compliance with the Ph. Eur. monograph and the aescin content before choosing a dossier partner.

Aesculus hippocastanum dosage forms and dossier types

Horse chestnut extract is marketed as prolonged-release tablets and capsules for oral use, and as creams and gels for topical use. Generic manufacturers most often develop prolonged-release oral forms, which carry the well-established-use indication.

Aesculus hippocastanum regulatory and patent status

The EMA’s Committee on Herbal Medicinal Products (HMPC) has published a monograph on horse chestnut seed. It supports well-established use of standardised oral extracts for chronic venous insufficiency. It also supports traditional use of topical preparations for mild venous discomfort and bruising. The monograph has been revised since its first version, so check the current wording for extract specifications before filing.

Horse chestnut extracts are off-patent, and quality is defined by the Ph. Eur. In the US, horse chestnut products are sold as dietary supplements, not approved drugs.

Aesculus hippocastanum mechanism of action and therapeutic use

Horse chestnut extract’s main active component, aescin, reduces capillary permeability and swelling. It also increases venous tone and has anti-inflammatory effects. Oral standardised extracts are used for chronic venous insufficiency, including pain, heaviness, cramps, itching and swelling in the legs. Topical preparations are used for mild venous discomfort, local swelling and bruising.

Aesculus hippocastanum licensing and sourcing

Horse chestnut extract suppliers and licensing partners typically offer dossier out-licensing, finished-product supply or extract supply. Buyers usually compare GMP status, extract standardisation, dossier type (well-established or traditional use) and territory availability. Current offers and supplier contacts are listed among the Aesculus hippocastanum manufacturers on Pipelinepharma.

Frequently asked questions about Aesculus hippocastanum

Who are the main Aesculus hippocastanum manufacturers?
Horse chestnut extracts are sold under brands such as Venostasin, Venoplant, Aescusan and Aesculaforce. Arkopharma and Herbapol also market horse chestnut products. Extract producers are concentrated in Europe.

Is a horse chestnut extract EU dossier available for licensing?
Yes. EU herbal dossiers for horse chestnut extract can be licensed as well-established-use (oral) or traditional-use (topical) applications. They must follow the HMPC monograph and Ph. Eur. quality standards.

What is the difference between horse chestnut extract and aescin?
Horse chestnut extract is a standardised herbal extract of the seed. Aescin is the purified saponin mixture that serves as its main active marker.

What forms of Aesculus hippocastanum are available?
Horse chestnut extract is available as prolonged-release tablets and capsules, typically equivalent to 50 mg aescin per dose, and as creams and gels. Bark extract is used in some rectal products.

Is horse chestnut extract approved in the US?
No. In the US, horse chestnut products are sold as dietary supplements, not approved medicines.