Ademetionine is a form of the amino acid methionine called S-adenosylmethionine, or SAMe. A
human body makes all the ademetionine it needs for good health in the normal course of life. But,
there are cases noted worldwide of low levels of methionine, folate, or vitamin B-12 can cause a drop
in ademetionine levels. Ademetionine doesn’t exist in our foods, so a synthetic version is used to
normalize levels in the body. Ademetionine plays a vital role in the immune system as it maintains cell
membranes, and helps produce and break down brain chemicals, such as serotonin, melatonin, and
Ademetionine is sold under the brand name Ademetionine amongst others.
Merck owns the patent for Ademetionine. It has been sold as a dietary supplement in the US since
1999, but it has been used as a prescription drug in Italy since 1979, in Spain since 1985, and in
Germany since 1989.
Dose and forms
Ademetionine tablets have to be swallowed whole and for best effects to be taken with meals. In the
treatment of Depression, the standard oral dose is 400-1600 mg per day, while the injectable dose is
200-400 mg/day. The standard dose indicated for the treatment of Osteoarthritis when taken orally is
200 mg thrice daily when through an injection it is 400 mg per day. In the treatment of Alcohol-Related
Liver Disease, the standard oral dose is 1200-1600 mg per day, and IV or IM dose of 200-2000 mg
per day for 15-30 days or 200 mg per day for 30 days is recommended. In the treatment of
Intrahepatic Cholestasis and Fibromyalgia, it is 800 mg twice a day.
The cost of Ademetionine
In the USA, the consumers have to pay approximately USD90 for a 50mg supply for this medicine.
Whereas in India, a tablet strip containing 30 tablets of 400mg strength is sold for USD 170.
How does Ademetionine work?
The body uses Ademetionine to make chemicals that play a role in pain, depression, liver disease,
and other conditions. People who don't make enough Ademetionine naturally are helped by taking
Ademetionine supplements. Ademetionine’s involvement in methylation assists in cellular growth and
repair maintains the phospho-bilipid layer in cell membranes. Ademetionine also helps maintain the
action of several hormones and neurotransmitters that affect mood.
Finding Ademetionine Manufacturers and Ademetionine Suppliers
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