topotecan hydrochloride Vials, lyophilized injection 4 mg

Dossier type
CTD
Dossier status
Ready to file
Country of origin
Turkey
GMP approvals
PICS
Manufacturer #1430

Manufacturer usually replies in 5 days

Topotecan Hydrochloride Manufacturers

Topotecan is an anti-cancer medication that is used to address ovarian cancer, minor cell lung disease, and uterine cancer. For the treatment of metastatic ovarian cancer in people who have had their disease recur or progress after receiving platinum-based chemotherapy. Used as a treatment session for care cell carcinoma, and in conjunction with cisplatin for the management of stage IV-B, recurring, or chronic uterine cancer that is not susceptible to therapeutic surgery and/or radiotherapy.

How Does Topotecan Hydrochloride Work?

Topotecan works in the same way as irinotecan, causing cytotoxicity during DNA synthesis's S phase. By causing reversible solitary breaks, prophase I relieve torsion tension in DNA. Topotecan interacts with the DNA gyrase I-DNA complex, preventing single-strand breaks from being relegated. This ternary complex obstructs the full and partial, causing replicating arrest and fatal double-stranded DNA breaks. The creation of this compound eventually leads to apoptosis in mammalian cells because they are unable to repair some double-strand DNA breaks. Topotecan intercalates between the downstream and upstream base pairs to attach to the region of DNA cleavage. The downstream DNA is displaced by intercalation, which prevents the broken strand from relegating. Topotecan works as a non - competitive antagonist by specifically attaching to the enzyme-substrate combination.

Wholesale Price of Topotecan Hydrochloride

According to the supplier you contact, topotecan intravenous powder for injection 4 mg costs roughly $152 for a batch of 1 powder for administration. Topotecan Hydrochloride is available for sale from a variety of Topotecan Hydrochloride vendors at a range of costs. Prices are applicable just for cash consumers and do not apply to insurance policies. Topotecan Hydrochloride suppliers, on the whole, are in favor of patient aid initiatives. This cost may differ among dealers. Its price may vary depending on the country of origin, wholesale costs incurred by manufacturing companies, supplier pricing, and similar factors. Pharmaceutical corporations generally support patient support programs.

Navigating our Pharmaceutical Marketplace

Being a global B2B pharmaceutical online marketplace, Pipelinepharma is structured to simplify pharmaceutical deals by providing you with an intuitive interface that is easy to engage with. The selection of Topotecan Hydrochloride offerings can be narrowed down with the use of filters and easily weighed against one another according to medication prices and commercial terms. The advanced filters help you filter out the countries for this substance manufacturer and Topotecan Hydrochloride suppliers that you are looking for. These also enable you to check the dossier status of this medicine, and the GMP approvals of the different variants of the Topotecan Hydrochloride. Also, each manufacturer or supplier product description contains essential information about this substance including clinical data, stability zones, countries where Topotecan Hydrochloride is already registered in. Manufacturers also have special, and delivery terms.

Establishing Commercial Ties

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Quality Assurance

To keep up to the quality standards other than Good Manufacturing Practice approvals that this medicine manufacturers list has, we qualify their companies before they are boarded on the platform. This allows us to screen Topotecan Hydrochloride manufacturers for the quality of the pharmaceutical products’ dossiers and protect against the risk of possible malpractices.