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terlipressin Injection 0.10 mg

Dossier type
CTD
Dossier status
Ready to file
Country of origin
India
GMP approvals
WHO
Manufacturer #31070

This pharmaceutical company is a leading global player with over 35 years of experience, operating in more than 60 countries across diverse regions. They specialize in manufacturing a wide range of pharmaceuticals, including prescription medications, over-the-counter drugs, and critical care products. Their extensive portfolio boasts over 350 marketed formulations and 1000+ product registrations, spanning numerous therapeutic areas like oncology, infectious diseases, cardiovascular health, and pain management. The company holds WHO GMP & ISO 9001:2015 certifications, reflecting their commitment to quality and regulatory compliance. Their state-of-the-art manufacturing facility in India utilizes cutting-edge technology and employs a highly skilled workforce dedicated to delivering affordable, high-quality products.

Terlipressin

Terlipressin is an analogue of vasopressin. It is used as a vasoactive drug in the management of Low Blood Pressure or hypotension. It has been found effective in patients whose other norepinephrine failed in the management of low blood pressure. It is also used in the treatment of bleeding esophageal varices and help prevent urination. Terlipressin is sold under the brand name Glycylpressin Ferring, Glypressin Biopas, and Ferring to name a few. Cyon Therapautics Inc filed the first patents for this medicine in but it was approved. Terlipressin is not sold available in the United States, or Canada, but it is available in New Zealand, Australia, Europe, India, Pakistan & UAE.

Forms and dose:

Terlipressin is available as an acetate, in 0.12 mg for ml solution, for an injection. For treating adults, initial dose starts at 1 to 2 mg of terlipressin acetate, that is also equivalent to 8.5 to 17 ml of solution. It is administered by intravenous injection over a period of time. The dose can vary by body weight with people less than 50kgs get 1mg dose and those exceeding 70kgs getting a dose of 2mg. After the initial dose, it is decreased to 1 mg acetate, given every 4 to 6 hours. The patients feels better after about 3 days of treatment.

The price of Terlipressin:

In the USA, the consumers have to pay USD 113 for a 10 vials fo 1ml solution. The 5mg vials costs USD 60, to 10mg cost USD84 and the 50Mg costs USD 204. The price of this medicine is significantly lower is the developing part of the world. India, the same injection of 1ml csots only about USD18.

How does it work?

Terlipressin is a naturally occurring hormone present in the body, known as antidiuretic hormone or vasopressin. This hormone has two main effects in the body namely causing narrowing of blood vessels called vasoconstriction that limits blood flow to a particular area of the body. Its actions also make kidney to retain water in the body, helping prevent excessive loss of water in the urine.

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