This pharmaceutical company, established in 1967, specializes in manufacturing and marketing a diverse range of ethical and generic pharmaceuticals. They offer products across key therapy areas like antibacterials/antifungals, gastrointestinal health, pain management (analgesics/antipyretics), and vitamins/hematinics. Their product portfolio includes master capsules, tablets, creams & ointments, drops, dry syrups, and injections. They prioritize quality, adhering to WHO/GMP standards, and boast a wide distribution network serving both domestic and international markets. Their focus on innovation is evident through upcoming product launches in areas like topical treatments and sugar-free syrup formulations.
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TAZOBACTAM
Tazobactam is a penicillin that is heavily modified and a sulfone. It inhibits the action of
bacterial β-lactamases, especially those belonging to the SHV-1 and TEM groups. Simply
put, it is an ingredient that can be added to certain antibiotics to make them less vulnerable
to bacteria's antimicrobial resistance. Tazobactam is commonly used as in its sodium salt,
tazobactam sodium form.
Tazobactam is combined with the extended-spectrum β-lactam antibiotic piperacillin in the
drug piperacillin/tazobactam, used in infections due to Pseudomonas aeruginosa.
Tazobactam expands the spectrum of activity by making it effective against organisms that
express β-lactamase and would normally degrade piperacillin.
Piperacillin with tazobactam is penicillin antibiotic used to treat different infections caused by
bacteria, like stomach, skin, pneumonia, and severe vaginal infections.
Tazobactam is sold under the brand name Zerbaxa, Zosyn amongst others.
Taiho Pharmaceutical Company filed some of the first patent related to making this medicine
in 1982 and came into medical use in 1992. Since then the patents have expired, many
other companies have made their formulations of this medicine.
Forms and dose:
Piperacillin is sold as Piperacillin/Tazobactam 4 g/0.5 g Powder for Solution for Infusion,
where 1 vial has 4 g piperacillin as sodium salt and 0.5 g tazobactam as the sodium salt.
The usual recommended adult dose is 4 g piperacillin / 0.5 g tazobactam administered every
eight hours. While treating nosocomial pneumonia and bacterial infections in neutropenic
patients, the usual recommended adult dose is 4 g piperacillin / 0.5 g tazobactam
administered every six hours.
For children under 2 years of age, the dose is 80 mg Piperacillin / 10 mg Tazobactam per
kilo of body weight given every six hours for treating Neutropenic children with fever
suspected to be due to bacterial infections. For treating Complicated intra-abdominal
infections, the recommended dose is 100 mg Piperacillin / 12.5 mg Tazobactam per kilo of
body weight given every eight hours.
The price of Tazobactam
In the USA, depending on the pharmacy and brands, for a supply of 10 powder for injection,
the consumers have to pay between $69.30 and $138.60. the same supply of 10 powder for
injection will cost around USD60 in India.
How does it work?
Tazobactam works by inhibiting the action of bacterial beta-lactamase producing organisms.
These are normally resistant to beta-lactam antibiotics. Tazobactam augments the efficacy
of antibiotic that would otherwise not be effective in treating certain infections.
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