spiramycin + metronidazole Tablets, film coated 1.5 MIU / 250mg

Spiramycin

Spiramycin is an antiparasitic and a macrolide antibiotic. it is prescribed to treat toxoplasmosis and various other infections of soft tissues. Most commonly, it treats toxoplasmosis in pregnant women since as it decreases the probability of infection in the unborn baby. Spiramycin was approved in the EU, Canada in 2000. However, it is still an experimental drug in the The United States, prescribed under special permission from the FDA for toxoplasmosis in the first trimester of pregnancy. PINNER- SINDICO isolated a 16-membered ring macrolide in 1954 as a product of Streptomyces ambofaciens. Oral use has been allowed since 1955 and the parenteral form was introduced into practice in 1987.

Dosage and administration

Spiramycin is best taken on an empty stomach and should be maintained at a constant level for best results. That is why the users should not miss any doses and take them evenly spaced times. For those using suppositories, the directions are to start by removing the foil wrapper and moisten the suppository with cold water and then insert is lying down as directed. The dose varies by the patient depending on their condition. The amount of medicine also is decided the strength and the number of doses taken each day. If taking the oral capsules or tablets to treat infections in adults and teenagers is 1 to 2 grams, two times a day, or 500 mg to 1 gram three times a day and increased to is 2 to 2.5 grams two times a day for severe infection. If taking injection treatment of infections, the dose is 500 mg injected slowly into a vein, every eight hours and 1 gram and severe infections. Consult the doctor for a pediatric dose.

The price of Spiramycin

In the USA, the cost of 10, 1 mL injections costs USD 79, for a supply of 100mg cost USD72. In India, Spiramycin Tablets cost around USD 17 for a box of 100 tablets each containing 3MIU.

How does Spiramycin work?

Spiramycin as an antibiotic inhibits protein synthesis in the bacterial cell during translocation. Those who use it frequently develop resistance by several mechanisms and its considerably prevalent. Spiramycin has an effective antibacterial spectrum against Gram-positive Gram-negative cocci and rods, and Legionellae, mycoplasmas, chlamydiae, types of spirochetes, Toxoplasma gondii, and Cryptosporidium species. Its main properties are bacteriostatic. It can exert a bactericide action on highly sensitive strains. Compared to erythromycin, the difference in effectiveness due to great affinity to tissues. It is because this is where it achieves the highest concentrations, higher than serum levels. its slow release of the antibiotic from the tissue compartment, the marked action on microbes in sub-inhibition concentrations, and the relatively long persisting post-antibiotic effect is due to its slow release.

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