The activity of the company is based on the development of highly competitive processes for the manufacture of active ingredients with high added value that meet the strictest quality specifications. They manufacture under strict compliance with the environmental and occupational safety regulations in force in Europe. They focus on the pharmaceutical, hospital, diagnostic, fine chemical, and food fields. Its products are marketed in more than 70 countries.
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Rasagiline
Rasagiline is used to treat symptoms in early Parkinson's disease as a monotherapy or in more
advanced cases as an adjunct therapy. It used to treat symptoms of Parkinson's disease both alone
and in combination with other drugs. It is effective in treating both early and advanced Parkinsons,
especially in dealing with non-motor symptoms like fatigue. It works by irreversibly inhibiting
monoamine oxidase- B.
In Parkinson's disease dopamine-producing cells die, with it, neurotransmitters. An enzyme called
monoamine oxidase is responsible for breaking down these neurotransmitters. Its two forms, MAO-
A and MAO-B. MAO-B breaks down dopamine. Rasagiline’s actions prevent this breakdown by
irreversibly binding to MAO-B. Therefore, making Dopamine available, which compensates, to
certain a extent, the decrease of quantities of dopamine produced in their brains.
Rasagiline is sold under the brand names Azilect, Azipron among others.
Aspro Nicholas invented the racemic form in the early 1970s. However, it was approved for sale in
Europe & the US in 2005 and 2006 respectively. It was identified as a potential drug for Parkinson's
disease was done by Moussa B.H. Youdim, with collaborators at Technion & Teva Pharmaceutical.
They identified the R-isomer as the active form of the drug. Teva markets it in partnership with
Lundbeck in Europe, the US, and elsewhere.
Dosage and Administration
Rasagiline is sold as a tablet in 1mg and 0.5mg strengths. In the treatment of Parkinson's Disease, when
used as monotherapy, the recommended dose is 1 mg a day and when being used as an Adjunct
without Levodopa, the initial dose is 0.5 mg, which may be increased to 1 mg/day as needed and
tolerated. The dosage modification should not exceed 0.5mg a day.
The price of Rasagiline
In the USA, a supply of 30 tablets of 1mg, will cost the consumer around $608.12. where as this
price is significant lower at USD 0.15 for a supply of 10 tablets in India.
How does it work?
Parkinson’s patient suffers a loss in the ability to produce enough dopamine in the brain, thus
decreasing the number of neurotransmitters in the brain. An enzyme called MAO-B is responsible for
this decrease. Rasagiline was the first selective MAO-B inhibitor that partly metabolizes into to l-
methamphetamine, one of the two methamphetamine enantiomers. These increase Rasagiline’s
ability to inhibit the reuptake of the neurotransmitters dopamine and norepinephrine. This allows for
the treating of orthostatic hypotension and hallucinations.
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