Oxaliplatin is chemotherapy used to treat advanced cancer of the colon and rectum. It works
by slowing or stopping the cancer cells from growing. it is a type of chemotherapy that
contains platinum and is administered together with other anticancer drugs, Fluorouracil, and
Leucovorin. Oxaliplatin has been found effective against the cancers that have already
spread. a three yearlong study of patients treated with Oxaliplatin found that the survival rate
amongst the Oxaliplatin-treated patients was 86%, making it one among the simplest drugs of
this type.
Oxaliplatin is sold under the name Eloxatin amongst others.
Professor Yoshinori Kidani of the Nagoya University was granted U.S. Patent in 1979. it had
been later in-licensed by Debiopharm and developed into advanced colorectal cancer
treatment. Debiopharm then further licensed the drug to Sanofi-Aventis in 1994.
Forms and Dosage
Oxaliplatin is sold as a powder for an injectable solution in 50mg, 100mg, and 200mg vials.
within the treatment of colorectal cancer, together with other drugs, the patient is given an
initial dose of 85 mg IV infusion to be administered over 120 minutes, every 2 weeks. For the
advanced stage of this cancer, the therapy goes on for 12 cycles, spanning 6 months. The
recommended dose is repeated every 2 weeks until the disease progresses or reaches levels of
unacceptable toxicity. It shouldn't tend to patients with renal impairment or hepatic
impairment.
The wholesale price of Oxaliplatin
Currently, consumers can purchase a 50mg supply of this medicine for USD93 within the
USA, the worth might be lower thanks to insurance and discounts offered by different
pharmacies. the typical price of monthly therapy within the USA is around USD 50. Whereas
in India it costs the patient about USD35 for an equivalent supply of Oxaliplatin.
How does Oxaliplatin work?
Oxaliplatin is an alkylating agent, that is most active within the resting phase of the cell.
Chemotherapy drugs kill cancer cells only they're dividing, these are called cell-cycle
specific. However, Oxaliplatin may be a non-cell-cycle agent, it attacks the cancer cells once
they are at rest. The schedule of chemotherapy is targeted towards a specific sort of cells,
they specialize in the speed of cellular multiplication, then the acceptable time it selected to
administer the therapy for optimum results.
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