Omega 3 fatty acids are lipid-regulating agents. They are an adjunct to diet to reduce
triglyceride levels in adult patients with severe, that is more than 500 mg/dL or greater,
hypertriglyceridemia. Ingestion of omega-3 PUFAs, abundant in fish oils, have potent actions on
several human disorders and diseases, including cardiovascular disease and cancer. they
reduce platelet activity, contributing to their potential cardiovascular benefits. Fish oil lowers
high triglyceride levels reducing the risk for heart disease and stroke. It also curbs stiffness and
joint pain in addition to boosting the effectiveness of anti-inflammatory drugs. It also plays a role
in important in visual and neurological development in infants. A diet rich in omega-3s lowers
inflammation, helping asthma patients heal and recover better. Some studies have also shown
that they can help in reducing symptoms of ADHD and Alzheimer’s and Dementia.
Omega−3 fatty acids are sold under the brand names Vascepa in the USA and Epadel among
others.
Efamol Holdings Plc filed the first patents for treating schizophrenia using essential fatty acid
compositions in 1988, since then several companies have made formulations for the treatment
of other conditions. In 2004, the FDA gave EPA and DHA omega−3 fatty acids, a "qualified
health claim" status, but said it has "supportive but not conclusive research shows that
consumption of EPA and DHA [omega−3] fatty acids may reduce the risk of coronary heart
disease’.
Dosage and administration
Omega−3 fatty acids are sold in Japan as capsules in 300mg, 600mg to 900mg strength
capsules for oral administration. The usual dose is 1.8 g per day and can be increased to 2.7g
a day if TG levels remain abnormal. IT can be taken two or three times daily after meals to
achieve the desired daily dose. In the USA, the brand available in 500-mg and 1000-mg
capsules at a dose of 4 g a day, to be taken orally as two 1000-mg capsules, or four 500-mg
capsules, twice daily with meals.
The price of Omega−3 fatty acids
In the international market, the consumers have to pay a retail price of $208.22. for the supply of
120 capsules of 1g strength. In India, the consumers have to pay the retail price of USD 9 for a
supply of 225grms of 1000mg strength.
How does it work?
They are characterized by the presence of a double bond three atoms away from the terminal
methyl group in their chemical structure. Omega-3 fatty acids help in reducing the risk of heart
disease. In combination with diet and exercise, it lowers levels of certain blood fat, (bad) and
raises levels of "good" cholesterol, called HDL.
Omega-3 fatty acids are eicosapentaenoic acid, alpha-linolenic acid, and docosahexaenoic
acid. ALA is found in plant oils such as flaxseed, soybean, and canola oils. DHA and EPA are
occurring naturally in fish and other seafood. Omega−3 fatty acids, also called Omega-3 oils are
polyunsaturated fatty acids.
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