ofloxacin
Solution for infusion
200 mg/100 ml
- 100 ml
Manufacturer usually replies in 8 days
Dossier type
CTD
Dossier status
Ready to file
Country of origin
Indonesia
GMP approvals
ID
Manufacturer #20982
Manufacturer usually replies in 8 days
Ofloxacin is a broad-spectrum fluoroquinolone antibiotic belongs to the drug class Fluoroquinolones. This medication is used to treat bacterial infections that cause bronchitis, pneumonia, chlamydia, gonorrhea, skin infections, urinary tract infections and infections of the prostate.
Ofloxacin is also used largely topically as eye and ear drops. Ofloxacin should be used only for infections that cannot be treated with safer antibiotics.
Manufacturers market Ofloxacin under the Brand name of Floxin, Floxin Otic, Ocuflox. Ofloxacin is advised as a prescription product as well as generic prescription product.
Ofloxacin is available in dosage form of Tablets, and Solution / Drops. Tablets are available in dosage strengths of 200 mg, 300 mg, and 400 mg, while solution is available in 3 mg /1 mL dosage strength. Tablets are administered orally and solution / drops are used topically as ear and eyes drops (Auricular / Ophthalmic).
The usual dose of Ofloxacin tablets is 200 mg to 400 mg orally for every 12 hours and the dosage varies depending upon the type of infection. For example, the dosage consideration for Bronchitis Exacerbation is 400 mg orally every 12 hours for 10 days, for Complicated Urinary Tract Infections 200 mg orally every 12 hours for 10 days, for Prostatitis 300 mg orally every 12 hours for 6 weeks and for Traveler’s Diarrhea (Off Label) 300 mg orally every 12 hours for 1-3 days.
Ofloxacin Tablet and Solution are recommended to be stored at 20° C to 25° C (68° F to 77° F), in well closed containers.
Wholesale Price of Ofloxacin
The wholesale price for 50 units of 200 mg Ofloxacin oral tablet is approximately $ 7.50 with per unit cost comes at as low as $ 0.15
The per unit cost of 300 mg Ofloxacin oral tablet is approximately $ 0.15 - $ 10.52, which is available for a price range of $ 7.50 - $ 525.97 for 50 tablets whereas for a set of 100 tablets it costs $ 948.20 and the per unit cost comes at $ 9.48
The wholesale price range of Ofloxacin 400 mg oral tablet is approximately $ 429.75 - $ 558.53 for a set of 100 tablets with per unit cost in the range of $ 4.30 - $ 5.59
Ofloxacin Ophthalmic Solution 0.3% is available for a wholesale price range of $ 7.50 - $ 20.94 for 5 milliliters and for 10 milliliters it costs around $ 7.50 - $ 32.39
Ofloxacin - Mechanism of Action
Ofloxacin is a bactericidal and broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. Ofloxacin mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. It involves in the inhibition of bacterial topoisomerase IV and DNA gyrase (both of which are type II topoisomerases), enzymes required for DNA replication, transcription, repair and recombination. By inhibiting their function, the drug thereby inhibits normal cell division.
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