Mirabegron treats overactive bladder. In this condition, the patient’s bladder muscles
contract uncontrollably. This leads to frequent urination, urgent need to urinate, and
inability to control urination. It can be used as a standalone therapy or in combination with
Solifenacin. It has properties similar to antimuscarinic medication like Solifenacin. Its actions
activate β3 adrenergic receptor in the bladder, leading to its relaxation.
Mirabegron is sold under the brand name Myrbetriq among others.
Astellas Pharma Inc. received the First approval for selling in the USA and EU in 2012. In
2017, with more than three million prescriptions, it was in the top 200 most prescribed
drugs in the USA.
Dosage Forms & Strengths
Mirabegron is sold as an extended-release tablet in 25mg and 50mg strengths. In the
treatment of overactive Bladder, as a Monotherapy, with symptoms of urge urinary
incontinence, urgency, and urinary frequency, the dose is 25 mg, per day and it is typically
effective within 2 months from the start of the therapy, the dosage can be increased to 50
mg a day dependent on individual efficacy and tolerance.
The price of Mirabegron
In the USA, the consumer has to pay an average retail price of $497.10 for 30 branded
tablets. This medicine is much cheaper in the developing part of the world. In India, a supply
of 30 tablets of 50mg of oral, tablets costs USD40.
How does Mirabegron work?
Mirabegron is a selective agonist for beta-3 adrenergic receptors with high potency. Upon
activation of the beta-3 receptors, the detrusor smooth muscle relaxes to allow for a larger
bladder capacity. At 200 mg doses (high), there is a potential to activate beta-1 and beta-2
adrenergic receptors. Its action results in the relaxation of the muscles around the bladder.
This eventually results in increased bladder capacity thus reducing the urge or need to pee
as frequently or as urgently.
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