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Mebendazole is a drug basically used for treating parasitic infestations. This covers giardia, hydatid disease, guinea worm infestations, hookworm infections, pinworm disease, and ascariasis among others. This anti-worm indication is to be taken orally and is well tolerated. The drug is a broad-spectrum anti-helminthic agent and prevents multiplication or hatching of insect larvae.
Mebendazole was developed in Belgium in 1971 by Janssen Pharmaceutica. The company is the leading Mebendazole manufacturer in the world. The drug has been included in the List of Essential Medicines by the World Health Organization. It is considered to be one of the most effective medicines required for a healthy system. It is also safe to use and is available as a generic medication for sale. The manufacturing of this drug has picked up momentum in recent years. Mebendazole suppliers are working round the clock to keep up with the demand for this drug.
The wholesale cost of this drug for the developing world is somewhere between US$0.004 to 0.04 per dose. In the UK, the drug costs about £7.99. Hence, there is a massive demand for offerings from Mebendazole manufacturers. As the wholesale cost is less, there are several health organizations that are promoting this drug for its effectiveness.
Mebendazole is highly effective in the treatment of infestation from nematodes which includes pinworm, threadworm, whipworm, hookworm, and roundworm. This drug is suitable for treating mild infestations as it cannot function well for treating infestations outside the digestive tract. This is because Mebendazole does not get absorbed into the bloodstream effectively. It kills parasites quite slowly. For heavy infestations, Piperazine is recommended by medical practitioners. This drug paralyzes the parasites thereby causing them to exit the human body through feces.
Mebendazole and other antihelminthic agents are active against both adult and larval stages of nematodes. It destroys the drug as well in case of whipworm and roundworm infestation. The death and paralysis of the parasites by this drug occurs slowly and complete elimination may require a couple of days.
Mebendazole functions by inhibiting the synthesis of microtubules selectively. The drug binds to colchicine binding sites thereby blocking polymerization in intestinal cells of parasites. This further blocks the uptake of nutrients and glucose which leads to the subsequent death of helminths. Poor absorption within the digestive track makes this quite an efficient drug for treating an infestation of parasites.
Mebendazole is available in the form of generic medication and is distributed by Johnson and Johnson in the international marketplace. Amedra Pharmaceuticals acquired the right of selling this pharmaceutical product in the United States in 2016 from Teva making them the largest distributors of the drug in the world. The company increased the drug price and also purchased the marketing rights from GSK in 2010. As a result, the price of this medication increased drastically and also the manufacturing demand. Mebendazole suppliers are quite optimistic about the potential of this drug in the marketplace.
Several research studies have demonstrated that Mebendazole has potential antitumor properties. Various studies are being carried out to understand the mechanism in which the drug functions while treating tumors. It has been established that this drug inhibits the growth, migration, and metastatic formation of adrenocortical carcinoma both in vivo and in vitro in cancer cells. While used to study the role of the drug in lung cancer treatment, it resulted in mitotic arrest followed by apoptotic cell death. Several preclinical studies are being carried out and case reports are being analyzed to understand the potential that Mebendazole holds. Sufficient experimental support and clinical studies are still needed to take a solid stand over this drug. This further boosts the prospects of the manufacturers and distributors of this drug.
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