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Lysozyme
Lysozyme is among the most potent natural antibacterial and antiviral compounds ever found.
Its actions naturally inhibit the growth of many spoilage organisms and thus has been used in
foods and pharmaceuticals for over three decades, where it increases healthy shelf life and
ensures food safety. Lysozyme boosts the immunity system. This enzyme occurs naturally in
bodily secretions like tears, saliva, and milk. It exerts is bactericidal actions and acts as an
antimicrobial agent as it cleaves the peptidoglycan component of bacterial cell walls, leading to
their death.
Its uses include resolving infections and inflammations and aid in wound repair, chronic
sinusitis, make it easy to clear phlegm in respiratory diseases, bleeding during or after minor
dental or urological surgeries.
Lysozyme is sold under the brand name inovapure™, amongst others. However, this is made
and used by companies around the world in several forms and applications.
Edward Abraham first crystallized Lysozyme in 1937. This enabled the description of the three-
dimensional structure of hen egg-white lysozyme in 1965 by David Chilton Phillips. He obtained
the first 200 pm resolution model via X-ray crystallography and presented the structure publicly
at a Royal Institution lecture.
Dosage and Administration
Lysozyme Hydrochloride is the most commonly available and used form of lysozyme salt. It is
sold to be used orally as tablets or capsules. The usual dose is 60mg to 270 mg, taken daily in 3
divided doses.
The price of Lysozyme
The medical-grade powder of Lysozyme costs around USD 136. The cost of Lysozyme, Salt-
Free Purified, twice crystallized, dialyzed, lyophilized powder costs USD 33 per gram for a
supply of ≥8,000 units per mg dry weight in the USA.
How does it work?
On its active site, it binds the peptidoglycan molecule in a cleft between its two domains.
Lysozyme actions attack peptidoglycans, that is in the cell walls of bacteria, especially Gram-
positive bacteria its natural substrate, between N-acetylmuramic acid and the fourth carbon
atom of N-acetylglucosamine.
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