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Gabapentin is a prescription drug in the class of medications known as anticonvulsants. It is used to treat seizures in people with epilepsy, as well as to treat nerve pain and certain other conditions.
Gabapentin works by reducing the activity of nerve cells in the brain and spinal cord. This helps to decrease abnormal electrical activity in the brain that can lead to seizures and also helps to reduce pain signals sent by damaged or overactive nerves.
Gabapentin is available in various forms, including capsules, tablets, and oral solutions. The drug is often used in combination with other medications to treat epilepsy and nerve pain. Gabapentin is sold under various brand names, including Neurontin and Gralise. Gabapentin is a controlled substance in some countries due to its risk of abuse and addiction.
Gabapentin is among the most prescribed medications, with over 44 million yearly prescriptions registered in the United States alone.
The dosage of Gabapentin depends on the condition being treated and the patient's age, weight, and kidney function.
The medication should be taken with food and plenty of water to help prevent stomach upset. Dosages may need to be adjusted for patients with kidney problems, and the medication should not be abruptly stopped without medical supervision.
The patent for Gabapentin has expired in many countries, including the United States, where it expired in 2004. This means that other manufacturers can now produce and sell generic versions of the medication. However, there may still be patents in effect in some countries that prevent other manufacturers from producing and selling generic versions.
Gabapentin was first developed by the pharmaceutical company Pfizer, and it was initially approved by the U.S. Food and Drug Administration (FDA) in 1993 for the treatment of seizures. Pfizer held the exclusive patent rights for Gabapentin until 2004, when the patent expired, allowing other companies to produce and sell generic versions of the medication.
After the patent expired, Gabapentin became available as a generic medication, which made it more affordable and accessible to patients. However, Pfizer also developed a modified-release formulation of Gabapentin, which is marketed under the brand name Gralise, and this formulation is still under patent in some countries.
Gabapentin is available under various brand names, including Neurontin, Gralise, Gabarone, Fanatrex, and Horizant.
In addition to the brand-name versions, Gabapentin is also available in generic form, which is sold under various brand names, including Gabapin, Gabantin, Gabamax, and others.
There are many manufacturers of Gabapentin worldwide, including major pharmaceutical companies such as Pfizer, which developed the drug, as well as other companies such as Teva Pharmaceuticals, Mylan, Dr. Reddy's Laboratories, Aurobindo Pharma, Glenmark, Actavis Elizabeth, Aurobindo Pharma, Amneal Pharmaceuticals, Apotex, Sun Pharmaceutical Industries, Hikma Pharmaceuticals, Mutual Pharmaceutical, Sandoz, Watson Laboratories, Akorn, Major Pharmaceuticals, Epic Pharma and others.
Depending on the brand and the quantity purchased, the wholesale prices of Gabapentin in the United States are the following:
These prices are estimates and can vary depending on various factors.
In the United Kingdom, the National Health Service (NHS) lists the drug tariff price for Gabapentin capsules at £1.67 for a pack of 100 x 100mg capsules and £4.04 for a pack of 100 x 300mg capsules. The drug tariff is the price paid by the NHS to pharmacies for prescription medications, which may differ from the wholesale price.
In other European countries, the wholesale price of Gabapentin may vary, and it is typically lower for generic versions of the medication. For example, in Germany, the wholesale price of generic Gabapentin 300mg capsules ranges from around €0.20 to €0.60 per capsule, while the wholesale price of branded Gabapentin formulations may be higher.
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