This company is a global manufacturer of essential lifesaving medicaments, specializing in high-tech parenteral and oral formulations. Established in 1984, it has grown from a small family business to a multinational corporation with over 2000 employees across 70 markets. Their expertise spans various therapeutic areas including anaesthesiology, critical care, pain management, gynaecology, ophthalmology, orthopaedics, oncology, and dermatology. They offer a diverse product portfolio of over 500 products, including injectables, infusions, and other dosage forms. The company prides itself on its commitment to quality, innovation, ethics, and transparency. They maintain GMP certifications and hold patents for several products. Their manufacturing sites are strategically located across key regions like the EU and North America.
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Doripenem
Doripenem is an antibiotic of the Carbapenem class. It is a beta-lactam antibiotic capable of killing
Pseudomonas aeruginosa. Doripenem is used to treat bacterial infections namely complex abdominal
infections, pneumonia contracted in hospital, and complicated infections of the urinary tract including
sepsis in the kidney infection. It has greater stability in aqueous solution compared to other
Carbapenem class antibiotics. Doripenem is administered as an infusion over 4 hours or more, which
is an advantage when treating difficult-to-treat infections. It also has a lower risk associated with
inducing seizures than other Carbapenem.
Doripenem is sold under the brand names Doribax and Finibax amongst others.
Shionogi Co. of Japan launched it under the brand name in 2005 and is marketed outside Japan by
Johnson & Johnson. Doripenem was approved by the USFDA in 2007, to be sold as Doribax. It is the
fourth carbapenem class drug to get approval in the United States. USFDA later revised the
Doripenem label in 2014 to include a warning against use in ventilator-associated pneumonia while
reiterating its safety and efficacy for its approved indications.
Forms and Dosage
Doripenem is sold as a powder for injection in a 500 mg vial. In the treatment of Complicated Intra-
abdominal Infection, the prescribed adult dosage is 500 mg IV infusion over 1 hour, given every 8hr
for 5-14 days. if there is an improvement in the condition, the doctor may switch to PO treatment. In
the treatment of Complicated UTI, the standard prescribed dose is 500 mg IV infusion over 1 hour
given every 8 hours for 10 days, which can be extended up to 14 days if needed. In the treatment of
Bronchopulmonary infection in patients with cystic fibrosis and who are colonized with Pseudomonas
aeruginosa or Burkholderia cepacia.
The Price of Doripenem
In the USA, the consumers pay around $182 for Doripenem intravenous powder for injection 250 mg
for a supply of 10 powder for injection. In the developing world countries, especially in India, the
medicine is significantly cheaper with the generic versions, with a starting price of the only USD20 for
the same 500 mg vial of powder for injection.
How does Doripenem work?
Doripenem is a beta-lactam antibiotic agent with a broad spectrum of bacterial sensitivity including
both gram-positive and gram-negative bacteria. In vivo, Doripenem blocks the synthesis of cell walls
by attaching itself to penicillin-binding proteins, But, it is not active against MRSA. Just like other beta-
lactam antibiotics, Its bactericidal actions mostly due to cell death after inhibition of bacterial enzymes
called penicillin-binding proteins.
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