It was founded in the 1990s with a mission to improve people’s health by developing safe and high-quality branded first generic medicines at affordable prices. This was at a time when several local and international pharmaceutical products were present in the local market but lacked alternative non-branded products, especially in the Central Nervous System (CNS) medicines. More than 20 years later, they remain committed to improving people’s health, enhancing medicines, and extending their reach to the communities in which they operate.
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DIMETHINDENE MALEATE
Dimetindene is a potent antipruritic antihistamine that is a selective H1 antagonist, used in
the symptomatic treatment of insect bites and sunburns. Its primary form Dimetindene is
used for curing allergic reactions like urticaria, allergies of the upper respiratory tract like
perennial rhinitis and hay fever, in curing food, and drug allergies, some pruritus, insect
bites. It is also used in the treatment of pruritus in eruptive skin diseases like chickenpox, as
an adjuvant in the treatment of eczema and other allergies of pruriginous dermatoses origin.
Its outstanding characteristic is the small size of its effective doses and the rapid onset of
action, which takes effect within 20 to 60 minutes and gives relief for several hours.
Dimetindene Maleate is sold under the trade name Forestal and Fenistil among others.
Novartis owns the current right for Dimetindene Maleate. However, it first came into use in
1960 after it was patented in the late 1950s.
Dosage and administrations
Dimetindene Maleate is sold as gel, emulsion, drops as well as a syrup that particularly for
use in children. One teaspoonful syrup contains 5ml of the drug that is equal to the 0.5mg
Coated tablets. The standard recommended dosage for adults is 3-6 tablets.
The standard dose varies by age, where if taking the Drops, the dose for Infants up to 1 year
is 10-30 drops, for Infants of 1 to 3 years age the dose is 30-45 drops, in treating Children
over 3 years, the dose recommended is 45-60 drops and for Adults, the dose is 60-120
drops.
If using the Syrup, the standard dose for infants up to 1 year is 1-3 teaspoons and for Infants
of 1 to 3 years, the dose is 3-4 teaspoons. For treating children over 3 years the dose is 4-6
teaspoons and for Adults, the dose is 6-12 teaspoons.
The cost of Dimetindene Maleate
In India, the consumers buy 250 Dimetindene Maleate Tablets of 1 Mg for as low as USD4.
In Europe, the oral drops of 20 ml cost around EUR 6.61, and the 0.1% concentration gel of
20ml cost around 9 pounds in the UK.
How does Dimetindene Maleate Work?
Dimethindene is a strong and selective histamine H1 antagonist. Its actions bind it to the
histamine H1 receptor competing with it. The result of this blocking is the action of
endogenous histamine. This whole process eventually leads to temporary relief from the
negative symptoms brought on by histamine generation in the body during an allergic
reaction.
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