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cinnarizine Tablets 25 mg, 75 mg

Dossier type
CTD
Dossier status
Ready to file
Country of origin
India
GMP approvals
WHO
Manufacturer #20488

This CTD dossier owner and manufacturer is based in South Asia and has been operating in the pharmaceutical market for over two decades. They focus on manufacturing and marketing pharmaceutical products, prioritizing quality and affordability. The company is GMP and ISO 9001:2015 certified, showcasing commitment to quality. They specialize in manufacturing various dosage forms, including oral and injectable medications. The company's product portfolio includes essential medicines targeting key therapy areas like diabetes, cardiology, and mental health. They also offer over-the-counter products. The company emphasizes a strong sales and marketing strategy with a dedicated team and reputed distributors to ensure product availability. While they don't explicitly mention specific patents, their commitment to market-oriented product upgrades suggests an ongoing pursuit of innovation.

Cinnarizine

Cinnarizine treats nausea and vomiting due to motion sickness, chemotherapy, vertigo, or Ménière's disease and Cogan's syndrome. An antihistamine is also a calcium channel blocker of the diphenylmethylpiperazine group. It has the rare distinction of having beneficial effect in the chronic treatment of the vertigo and tinnitus, associated with Meniere's disease. However, this medication causes drowsiness caused and is thus not or used very rarely amongst pilots and aircrew who must be dependably alert. British Royal Navy cited it as one of the most used drugs for seasickness. Cinnarizine is sold under the brand names such as Neurozine, Sezin and stugeron among others. Janssen Pharmaceutica first synthesized it in 1955. Cinnarizine, the nonproprietary name was given after the cinnamyl substituent on one of the nitrogen atoms. It combines with generic ending "-rizine" for antihistaminics or cerebral vasodilators. Cinnarizine is not available in the United States or Canada. However, it is sold in the EU and the rest of the world.

Dosage and administration

Cinnarizine is available as tablets of 15mg strength. While treating travel sickness, Adults and children aged 12 years or older are recommended to take two tablets two hours before travel, followed by one tablet every 8 hours during the journey, when needed. The dose for Children aged 5 to 11 years is one tablet, taken 2 hours before travel, followed by half a tablet every 8 hours during the journey when needed. When treating dizziness and sickness caused by inner ear problems, Adults and children aged 12 years or older are given two tablets to be taken 3 times a day and in Children aged 5 to 11 years, the dose is one tablet, taken 3 times a day.

The cost of Cinnarizine

In India, the consumers have pay a average retail price of USD1.5 for 25 tablets of to 25mg strength. This medicine is not sold in the US and Canada.

How does Cinnarizine Work?

Cinnarizine actions disrupt signal transmission between vestibular apparatus of the inner ear and hypothalamus, where the vomiting center in the brain resides. It does this by limiting the activity of the vestibular hair cells which send signals about movement. It is generally understood that, Vomiting in motion sickness is a compensatory mechanism of the brain, expressed physiologically. The confusion in brain whether the individual is moving or standing is reduced by abolishing the disparity of signal processing between inner ear motion receptors and the visual senses.

Finding Cinnarizine Manufacturers and Suppliers:

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