Celecoxib is a painkiller that is primarily used to treat inflammation and pain for patients with osteoarthritis, ankylosing spondylitis, heavy periods, and rheumatoid arthritis, among others. The drug is available in the form of 50mg, 100mg, 200mg, and 400mg celecoxib capsules. Celecoxib was developed by Searle & Company and first commercialized in 1990. Several years after its launch, Pfizer acquired full rights to celecoxib (marketed under the trade name Celebrex) and it became one of the flagship products of the supplier. After Pfizer's patent expired in 2014, other manufacturers and suppliers joined the celecoxib market. This served to reduce the price and expand the selection of celecoxib medications for retailers and patients alike. Currently, it is approved in and supplied to over 140 countries, with more than 6 million subscriptions recorded in 2016 in the U.S. alone. Both trade name and generic versions of celecoxib are widely available. Major generics manufacturers and suppliers Actavis, Mylan and Teva have launched their formulations of the drug. An higher risk of thrombotic events has been linked to celecoxib. The vasoconstrictive effects of thromboxane A2 cause increased platelet aggregation, which is unregulated when the acts of prostacyclin, a platelet aggregation blocker, are suppressed through the suppression of COX-2. This increases the risk of thrombosis associated with COX-2 inhibition.
How Does Celecoxib Work?
Non-steroidal anti-inflammatory medicines damage mucosa, lead to ulceration, and exacerbate existing ulcers throughout the intestinal system by suppressing prostaglandin synthesis. Due to its diminished impact on gastric mucosal upregulating when compared with placebo, celecoxib poses a lower risk of ulceration than other NSAIDS. By attaching to the cadherin-11 protein, which is known to be important in the development of cancers, and blocking the 3-phosphoinositide-dependent kinase-1 signalling pathway, celecoxib has anticancer effects. Furthermore, it has been discovered that celecoxib inhibits carbonic anhydrase enzymes 2 and 3, which strengthens its anticancer effects. Prostacyclin, thromboxane, prostaglandin D2, and prostaglandin F2 are among the metabolites whose synthesis is decreased when this enzyme is inhibited. Pain and inflammation are reduced as a result of the suppression of these mediators.
Wholesale Price of Celecoxib
The wholesale acquisition cost for a month's supply of celecoxib capsules in the U.S. is approximately 13 USD, whereas the retail price for the same amount in the EU is around 10-11 EUR. Costs of Celecoxib vary depending on manufacturer and supplier pricing, whether it is a generic or trade name formulation, concentration of the active ingredient in the formulation. Celecoxib is available for sale from various Celecoxib vendors at multiple costs. Prices are applicable just for cash consumers and do not apply to insurance policies. Celecoxib suppliers, on the whole, are in favor of patient aid initiatives.
From Where to Get Celecoxib?
Buyers are advised that online sellers may attempt to market fraudulent versions of the generic drug, whereas Pipeline Pharma, through its pre-auditing and quality control procedures ensures that only verified Celecoxib manufacturers and wholesalers enter our online marketplace, offering you a risk-free B2B pharmaceutical sales platform. PipelinePharma is the most reliable source for this medication. Finding an honest partner in our business is one of the significant challenges. To overcome this challenge and make one's life easier when looking for a direct manufacturer and supplier of Celecoxib, one can go to the Pipelinepharma website, which assists buyers in locating dependable manufacturers and suppliers of Celecoxib.
Navigating our Pharmaceutical Marketplace
Being a global B2B pharmaceutical online marketplace, Pipelinepharma is structured to simplify pharmaceutical deals by providing you with an intuitive interface that is easy to engage with. The selection of Celecoxib offerings can be narrowed down with filters and easily weighed against one another according to medication prices and commercial terms. The advanced filters help you filter out the countries for this substance manufacturer and Celecoxib suppliers that you are looking for. These also enable you to check the dossier status of this medicine and the GMP approvals of the different variants of Celecoxib. Also, each manufacturer or supplier product description contains essential information about this substance, including clinical data, stability zones, and countries in which Celecoxib is already registered. Manufacturers also have special delivery terms.
Establishing Commercial Ties
Suppose you are a pharmaceutical licensing company or a distributor. In that case, you can enter into deals or negotiations over these medicine offers with manufacturing companies after completing the free registration process and joining our online marketplace. This helps ensure that you conclude the pharmaceutical deal at a reasonable cost and achieve the best cost/benefit ratio for your company while bypassing lengthy sourcing, negotiation, and order process. Once you have finalized a deal, you can look forward to a long-lasting business relationship with the Celecoxib suppliers. This way, the marketplace allows you as a distributor to skip the process of making a list of product manufacturers every time you are looking for in-licensing or distribution deals.
To keep up to the quality standards other than Good Manufacturing Practice approvals that this medicine manufacturers list has, we qualify their companies before they are boarded on the platform. This allows us to screen Celecoxib manufacturers for the quality of the pharmaceutical products' dossiers and protect against the risk of possible malpractices.