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cefoxitin Injection 1000 mg, 1200 mg

Dossier type
CTD
Dossier status
Ready to file
Country of origin
India
GMP approvals
WHO
Manufacturer #19639

This globally operating pharmaceutical company focuses on developing and manufacturing a broad range of affordable medications. They specialize in both prescription and over-the-counter drugs, including oncology treatments, antibacterials, injectables (both specialty and large volume), ophthalmic products, dermatological preparations, and veterinary pharmaceuticals. Their product portfolio also includes unique niche drugs and orphan products, showcasing their commitment to addressing diverse medical needs. The company boasts state-of-the-art manufacturing facilities located across several regions, adhering to strict quality standards recognized by international regulatory bodies like the WHO GMP, US FDA, and MCC. Their extensive global reach spans over 45 countries in Asia, Africa, Latin America, CIS, Europe, Australia, and the Pacific Ocean. The company's focus on research and development, coupled with its global manufacturing capabilities and commitment to quality, positions them as a key player in the international pharmaceutical market.

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Cefoxitin

Cefoxitin is a second-generation cephamycin antibiotic. Cefoxitin is used to treat Aspiration Pneumonia, Cesarean Section, Gonococcal Infection – Uncomplicated, Intraabdominal Infection, Joint Infection, Osteomyelitis, Pelvic Inflammatory Disease, Peritonitis, Pneumonia, Septicemia, Bacterial Infection, Urinary Tract Infection, Skin and Structure Infection, Surgical Prophylaxis, Tuberculosis - Urinary Tract, Streptococcemia, Infection - Bacterial/Fungal/Protozoal/Viral and Endometritis. It is also given before surgery to prevent the development of surgical wound infections and in third and fourth-degree perineal injuries in women after giving vaginal birth. Cefoxitin decreases the infection rate at two and six weeks. Bioniche Pharma, LLC amongst others, sells Cefoxitin under the brand name Mefoxin. Merck Inc. developed Cefoxitin from Cephamycin C in the year following its discovery in 1972, when it was synthesized to create a broader spectrum antibiotic.

Dosage Forms & Strengths

Cefoxitin is available as tablets and injections. The injections are sold in three major IV doses of 1g, 2g, and 10g. In adults, Cefoxitin is administered every six to eight hours in 1g or 2g doses. In the treatment of Uncomplicated Infections, the usual recommended dose is 1 g, administered through Intravenous injections every 6 to 8 hours and for Moderate-Severe Infections, the dose is 1 g every 4 hours or 2 g every 6- 8 hours. The usual adult dose recommended in the treatment of Gas Gangrene or Infections commonly requiring antibiotics in a higher dosage is 2 g every 4 hours or 4 grams every 4 hours. For Prophylaxis post-Surgery, preventing infection post-Colorectal, non-perforated appendectomy or hysterectomy, and Ruptured viscus, the usual recommended adult dose is 1-2 g injected every 6 hours.

The price of Cefoxitin

In the USA, consumers have to pay around $430 for a supply of 10 powders for injection for 10 gm injection. In India, a supply of 1 gram of this powder in the ingredient form costs around USD25.

How does Cefoxitin work?

Cefoxitin is from a family of medicines called the beta-lactam antibiotic. This type of antibiotic binds to penicillin-binding proteins called transpeptidases. After binding to PBPs, its actions prevent PBPs from forming the cross-linkages between the peptidoglycan layers in the bacterial cell wall, interfering with cell wall synthesis. Cefoxitin is a bactericide that inhibits bacterial cell wall synthesis.

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