PipelinePharma Logo
PipelinePharma Logo

CTD Dossier Marketplace

Direct connection with CTD dossier (IP) owners and manufacturers

Marketing Authorizations Database

Search across marketing authorization registers
Sign in Get started

Generics

Innovative Products found!

Biosimilars

Medical devices

Nutraceuticals

Filters

Pp-219 manufacturers

Filters

1 products found

pp-219

Concentrate for solution for infusion

Dossier type
CTD
Dossier status
Under development
Country of origin
South Korea
GMP approvals
PICS
Comments
Indication: ICB-resistant advanced solid tumours (HCC, melanoma, RCC); R/R DLBCL post-anti-CD19 CAR-T (consolidation) Clinical stage: Phase 2 — CARNATION Phase 2a trial ongoing (R/R DLBCL consolidation post-CAR-T); Phase 2 combination with pembrolizumab (HCC/melanoma/RCC) initiated 2024 Modality: Biological (CD80-IL2v3 immunocytokine fusion protein — NBE) Mechanism / Target: CD80 domain binds CTLA-4 (checkpoint block) and CD28 (T cell co-stimulation); fused to IL-2v3 (IL-2 variant driving T cell and NK cell expansion/activation); dual immune checkpoint-blockade + cytokine stimulation in single bifunctional molecule; monotherapy ORR 18%, DCR 64% in checkpoint-refractory patients (ESMO 2025) Route / form: IV infusion (Q3W) Differentiation: First CD80-IL2 bifunctional immunocytokine; clinical monotherapy activity in ICB-refractory solid tumours; Phase 2a CARNATION trial ongoing for DLBCL consolidation post-CAR-T;
Manufacturer #39355
South Korea-based clinical-stage bio-venture developing Rx biologic drugs focused on immuno-oncology and inflammation/immunology. Lead injectable fusion-protein candidates are in clinical development. Advances a global clinical strategy through international regulatory engagements.

Want to see all products?

Subscribe today to benefit from:

  • Streamlined product sourcing - the leading CTD dossiers database focused on finished dosage formulations

  • Direct negotiations - connect and negotiate directly with manufacturers without any brokerage fee

  • Increased profitability - secure the best commercial terms for your business by comparing offers from several manufacturers

Request Subscription

Popular Searches

Amoxicillin manufacturers Atorvastatin manufacturers Benzocaine manufacturers Calcium carbonate manufacturers Cloperastine fendizoate manufacturers Gabapentin manufacturers Hyaluronic acid manufacturers Ibuprofen manufacturers Ivermectin manufacturers Levothyroxine manufacturers Lisinopril manufacturers Losartan manufacturers Magnesium manufacturers Melatonin manufacturers Metformin manufacturers Methotrexate manufacturers Metoprolol manufacturers Omeprazole manufacturers Paracetamol manufacturers Prednisone manufacturers Pregabalin manufacturers Semaglutide manufacturers Testosterone enanthate manufacturers Vitamin B12 manufacturers

Willing to unlock more features?

Please fill out form and send us your specific requirements, and we will get back to you as soon as possible

Want unlimited access to the Pipelinepharma database?

Become a subscriber to unlock:

  • Streamlined product sourcing: access the only CTD dossier pipeline and sourcing platform.

  • Direct connections: communicate directly with CTD dossier owners and manufacturers with no brokerage fees.

  • Higher profitability: compare multiple supplier offers and secure the best commercial terms.

  • Expanded network: view supplier portfolios and stay updated on new products.

  • Value-added product ideas: discover products with lower competition potential.

  • Access to marketing authorizations for sale: find already registered products in your target markets.