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pp-207

Cream

Dossier type
EU CTD
Dossier status
Under development
Country of origin
European Union
GMP approvals
EU GMP
Comments
Indication: Erythromelalgia — rare painful peripheral vascular disorder causing severe burning pain in extremities Clinical stage: Phase 2 data positive; FDA-guided development into Phase 2/3 Modality: Small molecule (TRPV1 receptor antagonist) Mechanism / Target: Topical TRPV1 (transient receptor potential vanilloid type 1) receptor antagonist; blocks peripheral nociceptor heat-pain signalling at the site of erythromelalgia; topical delivery avoids systemic hyperthermia associated with oral TRPV1 blockers Route / form: Topical cream/gel (applied to affected extremities) Differentiation: First TRPV1 antagonist in development for erythromelalgia; topical formulation uniquely avoids systemic TRPV1 side effects (hyperthermia/reduced body temperature regulation);
Manufacturer #39344
Europe-based publicly listed pharmaceutical company developing Rx small-molecule treatments for CNS disorders, including Alzheimer's disease and pain. Multiple oral candidates advance through proprietary research platforms at clinical and preclinical stages.

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