MICONAZOLE NITRATE

Miconazole nitrate is an azole antifungal. It used treating used to treat vaginal yeast infections. Miconazole reduces vaginal burning, itching, and discharge associated with these infections. It also used to treat skin infections caused by fungus. These infections include athlete's foot, ringworm, jock itch. It also reduces the red skin patches, itching, and peeling that occur with these skin infections. As an antifungal, it works by stopping the growth of fungus. Miconazole nitrate is sold under the brand name Aloe Vesta 2-N-1 Antifungal, Baza Antifungal, Carrington Antifungal, Derma Gran AF amongst others. However, given the nature of infections it cures, it is available in several forms. INSIGHT Pharmaceuticals first synthesized Miconazole nitrate in 1969. It was granted FDA approval in 1974 for sale by as a topical cream. Since then several more patents for formulations have been filed and it is widely used around the world. It is a highly effective and safe medicine, qualities which have earned it a place on WHO’s List of Essential Medicines.

Forms and Dosage:

Miconazole nitrate is available as a tablet, topical cream, vaginal suppository, topical get, lotion, ointment, powder, powder spray, solution, and vaginal cream. While using vaginal cream, the first step is to Lie down on your back. Then Insert one applicator filled with cream into the vagina as far as it will comfortably go. Slowly press the plunger to apply the cream. If using the vaginal tablet, use the applicator or finger to insert the tablet. Fill the applicator with the vaginal tablet. Repeat the process above. Women are recommended not to use tampons, douches, spermicides, or other vaginal products while using this medication. To treat Athlete's foot and ringworm, the normal course of treatment is 4 weeks. Jock itch takes 2 weeks to cure.

The Price of Miconazole nitrate:

In the USA, the price of the topical cream with 2% MN is around $11 for a supply of 14 grams. Likewise, the Vaginal Cream with Applicator costs $15.30 for a supply of 45 grams, the Vaginal Kit with 200mg of 2%, costs 17.34 per kit, and the Vaginal Suppository of 100 mg, cost 14USD for seven suppositories. In India, the price of the topical cream, for a supply of 2 grams is around $2. Whereas the skin cream costs $0.1 for a supply of 5 grams.

How does Miconazole nitrate work?

Miconazole nitrate inhibits ergosterol from getting synthesized, a major component of fungal cell membranes. This inhibiting action interferes with the barrier function of the membrane and with the membrane-bound enzymes. However, its exact mechanism of action is unknown.

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